Previous genome-wide association studies have identified a strong association between FTO and human obesity, although the mechanism by which FTO affects obesity remains unknown. A new study suggests that the obesity risk alleles are gain-of-function.
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Stratigopoulos, G., Leibel, R. FTO gains function. Nat Genet 42, 1038–1039 (2010). https://doi.org/10.1038/ng1210-1038
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DOI: https://doi.org/10.1038/ng1210-1038