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LincRNAs join the pluripotency alliance

Nature Genetics volume 42, pages 1035–1036 (2010)Cite this article

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A new study shows that somatic cell reprogramming is accompanied by changes in the expression of large intergenic non-coding RNAs (lincRNAs). Some of these reprogramming-induced lincRNAs are directly targeted by key pluripotency factors and regulate reprogramming, implicating lincRNAs in the reinstatement and maintenance of pluripotency.

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Figure 1: Expression of lincRNAs in iPSCs.

References

  1. Ponting, C.P., Oliver, P.L. & Reik, W. Cell 136, 629–641 (2009).

    Article  CAS  PubMed  Google Scholar 

  2. Guttman, M. et al. Nature 458, 223–227 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Loewer, S. et al. Nat. Genet. 42, 1113–1117 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Feng, B., Ng, J.-H., Heng, J.-C.D. & Ng, H.-H. Cell Stem Cell 4, 301–312 (2009).

    Article  CAS  PubMed  Google Scholar 

  5. Judson, R.L., Babiarz, J.E., Venere, M. & Blelloch, R. Nat. Biotechnol. 27, 459–461 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Krizhanovsky, V. & Lowe, S.W. Nature 460, 1085–1086 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Huarte, M. et al. Cell 142, 409–419 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Rinn, J.L. et al. Cell 129, 1311–1323 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Zhao, J., Sun, B.K., Erwin, J.A., Song, J.-J. & Lee, J.T. Science 322, 750–756 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Nagano, T. et al. Science 322, 1717–1720 (2008).

    Article  CAS  PubMed  Google Scholar 

  11. Khalil, A.M. et al. Proc. Natl. Acad. Sci. USA 106, 11667–11672 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Dinger, M.E. et al. Genome Res. 18, 1433–1445 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Ørom, U.A. et al. Cell 143, 46–58 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Chen, X. et al. Cell 133, 1106–1117 (2008).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

J.-H.N. is supported by the A*STAR Graduate Scholarship. We are grateful to the Biomedical Research Council, Agency for Science, Technology and Research, Singapore.

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Authors and Affiliations

  1. Jia-Hui Ng is at the Gene Regulation Laboratory, Genome Institute of Singapore, Singapore and the Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.,

    Jia-Hui Ng

  2. the Department of Biochemistry, the Department of Biological Sciences, Huck-Hui Ng is at the Gene Regulation Laboratory, Genome Institute of Singapore, Singapore, National University of Singapore, Singapore, National University of Singapore, Singapore and the School of Biological Sciences, Nanyang Technological University, Singapore.,

    Huck-Hui Ng

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  1. Jia-Hui Ng
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Correspondence to Huck-Hui Ng.

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Ng, JH., Ng, HH. LincRNAs join the pluripotency alliance. Nat Genet 42, 1035–1036 (2010). https://doi.org/10.1038/ng1210-1035

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