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Cell cycle micromanagement in embryonic stem cells

Embryonic stem (ES) cells undergo rapid cell division without compromising their ability to differentiate into virtually all cell types. Using ES cells deficient for a microRNA biogenesis factor, Dgcr8, a new report uncovers the importance of specific microRNAs in the ES cell cycle transition from G1 to S phase.

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Figure 1: MicroRNAs regulate cell proliferation in ES cells.


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Kim, V. Cell cycle micromanagement in embryonic stem cells. Nat Genet 40, 1391–1392 (2008).

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