Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cell cycle micromanagement in embryonic stem cells

Nature Genetics volume 40, pages 1391–1392 (2008)Cite this article

Embryonic stem (ES) cells undergo rapid cell division without compromising their ability to differentiate into virtually all cell types. Using ES cells deficient for a microRNA biogenesis factor, Dgcr8, a new report uncovers the importance of specific microRNAs in the ES cell cycle transition from G1 to S phase.

miRNAs under suspicion

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it

$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Figure 1: MicroRNAs regulate cell proliferation in ES cells.

References

  1. Wang, Y. et al. Nat. Genet. 40, 1478–1482 (2008).

    Article  CAS  Google Scholar 

  2. Kim, V.N. Nat. Rev. Mol. Cell Biol. 6, 376–385 (2005).

    Article  CAS  Google Scholar 

  3. Murchison, E.P., Partridge, J.F., Tam, O.H., Cheloufi, S. & Hannon, G.J. Proc. Natl. Acad. Sci. USA 102, 12135–12140 (2005).

    Article  CAS  Google Scholar 

  4. Kanellopoulou, C. et al. Genes Dev. 19, 489–501 (2005).

    Article  CAS  Google Scholar 

  5. Wang, Y., Medvid, R., Melton, C., Jaenisch, R. & Blelloch, R. Nat. Genet. 39, 380–385 (2007).

    Article  CAS  Google Scholar 

  6. Houbaviy, H.B., Murray, M.F. & Sharp, P.A. Dev. Cell 5, 351–358 (2003).

    Article  CAS  Google Scholar 

  7. Suh, M.R. et al. Dev. Biol. 270, 488–498 (2004).

    Article  CAS  Google Scholar 

  8. Hatfield, S.D. et al. Nature 435, 974–978 (2005).

    Article  CAS  Google Scholar 

  9. Benetti, R. et al. Nat. Struct. Mol. Biol. 15, 268–279 (2008).

    Article  CAS  Google Scholar 

  10. Sinkkonen, L. et al. Nat. Struct. Mol. Biol. 15, 259–267 (2008).

    Article  CAS  Google Scholar 

  11. Marson, A. et al. Cell 134, 521–533 (2008).

    Article  CAS  Google Scholar 

  12. Voorhoeve, P.M. et al. Cell 124, 1169–1181 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. V. Narry Kim is at the School of Biological Sciences, BK21 program and National Creative Research Initiatives Center, Seoul National University, Seoul 151-742, Korea. narrykim@snu.ac.kr,

    V Narry Kim

Authors
  1. V Narry Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kim, V. Cell cycle micromanagement in embryonic stem cells. Nat Genet 40, 1391–1392 (2008). https://doi.org/10.1038/ng1208-1391

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng1208-1391

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing