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Stalled polymerases and transcriptional regulation

After initiating transcription, RNA polymerase II often stalls a short distance downstream of promoters. The recent discovery of stalled polymerases at a large number of eukaryotic promoters suggests that the regulation of stalling plays a more important role in gene expression and development than previously suspected.

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Figure 1: Transcription by RNA polymerase II.

Kim Caesar


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Tamkun, J. Stalled polymerases and transcriptional regulation. Nat Genet 39, 1421–1422 (2007).

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