Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Making the commitment to meiosis

Analysis of the phenotype of mouse germ cells deficient for the retinoic acid–responsive gene Stra8 provides insight into the timing of the commitment to enter meiosis in mammals. The observations suggest that, as in other eukaryotes, this commitment precedes (or coincides with) the commitment to premeiotic DNA replication.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: This flowchart depicts the steps of mammalian gametogenesis with an emphasis on the progression through mitosis and meiosis.


  1. Baarends, W.M., van der Laan, R. & Grootegoed, J.A. Reproduction 121, 31–39 (2001).

    Article  CAS  Google Scholar 

  2. Eddy, E.M. Recent Prog. Horm. Res. 57, 103–128 (2002).

    Article  CAS  Google Scholar 

  3. Bowles, J. et al. Science 312, 596–600 (2006).

    Article  CAS  Google Scholar 

  4. Koubova, J. et al. Proc. Natl. Acad. Sci. USA 103, 2474–2479 (2006).

    Article  CAS  Google Scholar 

  5. Baltus, A.E. et al. Nat. Genet. 38, 1430–1434 (2006).

    Article  CAS  Google Scholar 

  6. Handel, M.A. Theriogenology 49, 423–430 (1998).

    Article  CAS  Google Scholar 

  7. Wolgemuth, D.J., Laurion, E. & Lele, K.M. Recent Prog. Horm. Res. 57, 75–101 (2002).

    Article  CAS  Google Scholar 

  8. Morelli, M.A. & Cohen, P.E. Reproduction 130, 761–781 (2005).

    Article  CAS  Google Scholar 

  9. Matzuk, M.M. & Lamb, D.J. Nat. Cell Biol. 4, s41–s49 (2002).

    Article  Google Scholar 

  10. Chu, D.S. et al. Nature 443, 101–105 (2006).

    Article  CAS  Google Scholar 

  11. Gattiker, A., Niederhauser-Wiederkehr, C., Moore, J., Hermida, L. & Primig, M. Nucleic Acids Res. (in the press).

  12. Oulad-Abdelghani, M. et al. J. Cell Biol. 135, 469–477 (1996).

    Article  CAS  Google Scholar 

  13. Monesi, V. J. Cell Biol. 14, 1–18 (1962).

    Article  CAS  Google Scholar 

  14. Forsburg, S.L. & Hodson, J.A. Nat. Genet. 25, 263–268 (2000).

    Article  CAS  Google Scholar 

  15. Hollingsworth, R.E. Jr, & Sclafani, R.A. Chromosoma 102, 415–420 (1993).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Wolgemuth, D. Making the commitment to meiosis. Nat Genet 38, 1362–1363 (2006).

Download citation

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing