Analysis of the phenotype of mouse germ cells deficient for the retinoic acid–responsive gene Stra8 provides insight into the timing of the commitment to enter meiosis in mammals. The observations suggest that, as in other eukaryotes, this commitment precedes (or coincides with) the commitment to premeiotic DNA replication.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Baarends, W.M., van der Laan, R. & Grootegoed, J.A. Reproduction 121, 31–39 (2001).
Eddy, E.M. Recent Prog. Horm. Res. 57, 103–128 (2002).
Bowles, J. et al. Science 312, 596–600 (2006).
Koubova, J. et al. Proc. Natl. Acad. Sci. USA 103, 2474–2479 (2006).
Baltus, A.E. et al. Nat. Genet. 38, 1430–1434 (2006).
Handel, M.A. Theriogenology 49, 423–430 (1998).
Wolgemuth, D.J., Laurion, E. & Lele, K.M. Recent Prog. Horm. Res. 57, 75–101 (2002).
Morelli, M.A. & Cohen, P.E. Reproduction 130, 761–781 (2005).
Matzuk, M.M. & Lamb, D.J. Nat. Cell Biol. 4, s41–s49 (2002).
Chu, D.S. et al. Nature 443, 101–105 (2006).
Gattiker, A., Niederhauser-Wiederkehr, C., Moore, J., Hermida, L. & Primig, M. Nucleic Acids Res. (in the press).
Oulad-Abdelghani, M. et al. J. Cell Biol. 135, 469–477 (1996).
Monesi, V. J. Cell Biol. 14, 1–18 (1962).
Forsburg, S.L. & Hodson, J.A. Nat. Genet. 25, 263–268 (2000).
Hollingsworth, R.E. Jr, & Sclafani, R.A. Chromosoma 102, 415–420 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wolgemuth, D. Making the commitment to meiosis. Nat Genet 38, 1362–1363 (2006). https://doi.org/10.1038/ng1206-1362
Issue Date:
DOI: https://doi.org/10.1038/ng1206-1362