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Aging (not so) gracefully

Although the correlation between maternal age and meiotic nondisjunction in human oocytes is widely recognized, the underlying molecular defects are largely unknown. New evidence from mice lacking SMC1β suggests that high levels of chromosome mis-segregation in older oocytes may be due in part to deterioration of meiotic sister-chromatid cohesion during aging.

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Figure 1: The consequences of gradual loss of cohesion in human oocytes during aging.


  1. Hassold, T. & Hunt, P. Nat. Rev. Genet. 2, 280–291 (2001).

    Article  CAS  PubMed  Google Scholar 

  2. Hodges, C.A., Revenkova, E., Jessberger, R., Hassold, T. & Hunt, P.A. Nat. Genet. 37, 1351–1355 (2005).

    Article  CAS  PubMed  Google Scholar 

  3. Lee, J.Y. & Orr-Weaver, T.L. Annu. Rev. Cell Dev. Biol. 17, 753–777 (2001).

    Article  CAS  PubMed  Google Scholar 

  4. Nasmyth, K. Annu. Rev. Genet. 35, 673–745 (2001).

    Article  CAS  PubMed  Google Scholar 

  5. Prieto, I. et al. Nat. Cell Biol. 3, 761–766 (2001).

    Article  CAS  PubMed  Google Scholar 

  6. Revenkova, E., Eijpe, M., Heyting, C., Gross, B. & Jessberger, R. Mol. Cell Biol. 21, 6984–6998 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Revenkova, E. et al. Nat. Cell Biol. 6, 555–562 (2004).

    Article  CAS  PubMed  Google Scholar 

  8. Darlington, C.D. Recent Advances in Cytology (Churchill, London, 1932).

    Google Scholar 

  9. Buonomo, S.B. et al. Cell 103, 387–398 (2000).

    Article  CAS  PubMed  Google Scholar 

  10. Bickel, S.E., Orr-Weaver, T. & Balicky, E.M. Curr. Biol. 12, 925–929 (2002).

    Article  CAS  PubMed  Google Scholar 

  11. Wolstenholme, J. & Angell, R.R. Chromosoma 109, 435–438 (2001).

    Article  Google Scholar 

  12. Lamb, N.E., Yu, K., Shaffer, J., Feingold, E. & Sherman, S.L. Am. J. Hum. Genet. 76, 91–99 (2005).

    Article  CAS  PubMed  Google Scholar 

  13. Jeffreys, C.A., Burrage, P.S. & Bickel, S.E. Curr. Biol. 13, 498–503 (2003).

    Article  CAS  PubMed  Google Scholar 

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Bickel, S. Aging (not so) gracefully. Nat Genet 37, 1303–1304 (2005).

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