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TRAPping enhancer function

Nature Genetics volume 32, pages 555556 (2002) | Download Citation

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Enhancer elements act from distal regions to mediate the transcription of genes. A novel combination of FISH and ChIP techniques may provide new insight into the mechanism by which enhancer elements exert their control. Application of the technique to the Hbb (encoding β-globin) locus control region (LCR) suggests that elements of the LCR may be in close proximity to the transcribed β-globin genes.

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Author information

Affiliations

  1. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98125, USA.

    • Michael Bulger
    •  & Mark Groudine
  2. Department of Radiation Oncology, University of Washington Medical School, Seattle, Washington 98195, USA.

    • Mark Groudine

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DOI

https://doi.org/10.1038/ng1202-555

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