Enhancer elements act from distal regions to mediate the transcription of genes. A novel combination of FISH and ChIP techniques may provide new insight into the mechanism by which enhancer elements exert their control. Application of the technique to the Hbb (encoding β-globin) locus control region (LCR) suggests that elements of the LCR may be in close proximity to the transcribed β-globin genes.
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Bulger, M., Groudine, M. TRAPping enhancer function. Nat Genet 32, 555–556 (2002). https://doi.org/10.1038/ng1202-555
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DOI: https://doi.org/10.1038/ng1202-555
