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p53 and p73: seeing double?

Whereas p73 is closely related to the tumour-suppressor protein p53, its contribution to tumour suppression and the spatial and temporal regulation of its isoforms is unclear. It has now been established that p73 is a transcriptional target of E2F1. Its ability to induce apoptosis in TP53−/− cells indicates a tumour-control mechanism that runs parallel to but independent of that mediated by p53. The new results illustrate a complex cross-talk between p53, E2F1 and p73.

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Figure 1: A schematic representation of the gene structure of the different p53 family members.
Figure 2: E2F1 can act as a tumour suppressor or as an oncogene.

References

  1. Giaccia, A.J. & Kastan, M.B. Genes Dev. 12, 2973–2983 (1998).

    Article  CAS  Google Scholar 

  2. Caspari, T. Curr. Biol. 10, R315–317 (2000).

    Article  CAS  Google Scholar 

  3. Stiewe, T. & Pützer, B.M. Nature Genet. 26, 464–469 ( 2000).

    Article  CAS  Google Scholar 

  4. Lissy, N.A., Davis, P.K., Irwin, M., Kaelin, W.G. Jr & Dowdy, S.F. Nature 407, 642–645 (2000).

    Article  CAS  Google Scholar 

  5. Irwin, M. et al. Nature 407, 645–648 (2000).

    Article  CAS  Google Scholar 

  6. Kaelin, W.G. Jr Oncogene 18, 7701–7705 ( 1999).

    Article  CAS  Google Scholar 

  7. Lohrum, M.A. & Vousden, K.H. Trends Cell Biol. 10, 197–202 ( 2000).

    Article  CAS  Google Scholar 

  8. Yang, A. et al. Nature 404, 99–103 (2000).

    Article  CAS  Google Scholar 

  9. Ikawa, S., Nakagawara, A. & Ikawa, Y. Cell Death Differ. 6, 1154– 1161 (1999).

    Article  CAS  Google Scholar 

  10. Sherr, C.J. &. Weber, J.D. Curr. Opin. Genet. Dev. 10, 94–99 ( 2000).

    Article  CAS  Google Scholar 

  11. Yamasaki, L. et al. Cell 85, 537–548 (1996).

    Article  CAS  Google Scholar 

  12. Schmitt, C.A. & Lowe, S.W. J. Pathol. 187, 127–137 (1999).

    Article  CAS  Google Scholar 

  13. Di Como, C.J. Gaiddon, C. & Prives, C. Mol. Cell. Biol. 19, 1438– 1449 (1999).

    Article  CAS  Google Scholar 

  14. Marin, M.C. et al. Nature Genet. 25, 47– 54 (2000).

    Article  CAS  Google Scholar 

Download references

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Soengas, M., Lowe, S. p53 and p73: seeing double?. Nat Genet 26, 391–392 (2000). https://doi.org/10.1038/82497

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