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p53 and p73: seeing double?

Whereas p73 is closely related to the tumour-suppressor protein p53, its contribution to tumour suppression and the spatial and temporal regulation of its isoforms is unclear. It has now been established that p73 is a transcriptional target of E2F1. Its ability to induce apoptosis in TP53−/− cells indicates a tumour-control mechanism that runs parallel to but independent of that mediated by p53. The new results illustrate a complex cross-talk between p53, E2F1 and p73.

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Figure 1: A schematic representation of the gene structure of the different p53 family members.
Figure 2: E2F1 can act as a tumour suppressor or as an oncogene.


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Soengas, M., Lowe, S. p53 and p73: seeing double?. Nat Genet 26, 391–392 (2000).

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