The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

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Figure 1: Mutations of MBD4 at coding (A)10 and (A)6 tracks in MSI carcinomas and cell lines.


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We thank P. Tsichlis and A. Knudson for advice and encouragement; P. Engstrom for support; S. Litwin for statistical analysis; L. Cicchillitti for technical assistance; A. Tosolini for assistance with FISH mapping; and W. Kruger for critical reading of the manuscript. This work was supported by American Cancer Society grant IRG-191, Public Health Service grants CA78412 and CA70328, the Aaron Gold Cancer Prevention Research Fund, the McGorty Foundation, the Millie and Julius Roden Memorial Research Fund, the Italian Association for Cancer Research Special Project 'Hereditary Colorectal Tumors' and Italian National Research Council contract no. 97.04207.CT04. Additional support was provided by Public Health Service grant CA-06927 and by an appropriation from the Commonwealth of Pennsylvania to the Fox Chase Cancer Center.

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Correspondence to Alfonso Bellacosa.

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Riccio, A., Aaltonen, L., Godwin, A. et al. The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability. Nat Genet 23, 266–268 (1999).

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