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Stable dicentric X chromosomes with two functional centromeres

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Figure 1: Structure and stability of dicentric X chromosomes.


  1. Willard, H.F. Curr. Opin. Genet. Dev. 8, 219–225 (1998).

    CAS  Article  Google Scholar 

  2. Harrington, J.J., VanBokkelen, G., Mays, R.M., Gustashaw, K. & Willard, H.F. Nature Genet. 15, 345–355 (1997).

    CAS  Article  Google Scholar 

  3. Ikeno, M. et al. Nature Biotech. 16, 431– 439 (1998).

    CAS  Article  Google Scholar 

  4. Pluta, A.F., Mackay, A.M., Ainsztein, A.M., Goldberg, I.G. & Earnshaw, W.C. Science 270, 1591–1594 (1995).

    CAS  Article  Google Scholar 

  5. Warburton, P.E. et al. Curr. Biol. 7, 901– 904 (1997).

    CAS  Article  Google Scholar 

  6. Sullivan, B.A. & Schwartz, S. Hum. Mol. Genet. 4, 2189–2197 (1995).

    CAS  Article  Google Scholar 

  7. McClintock, B. Proc. Natl Acad. Sci. USA 25, 405– 416 (1939).

    CAS  Article  Google Scholar 

  8. Koshland, D., Rutledge, L., Fitzgerald–Hayes, M. & Hartwell, L.H. Cell 48, 801– 812 (1987).

    CAS  Article  Google Scholar 

  9. Lukaszewski, A.J. Genetics 140, 1069–1085 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Earnshaw, W.C. & Migeon, B.R. Chromosoma 92, 290–296 (1985).

    CAS  Article  Google Scholar 

  11. Hsu, L.Y. et al. J. Med. Genet. 15, 222– 226 (1978).

    CAS  Article  Google Scholar 

  12. Therman, E., Sarto, G.E. & Patau, K. Hum. Genet. 72, 191– 195 (1986).

    CAS  Article  Google Scholar 

  13. Wolff, D.J., Miller, A.P., Van Dyke, D.L., Schwartz, S. & Willard, H.F. Am. J. Hum. Genet. 58, 154–160 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Page, S.L. & Shaffer, L.G. Chromosome Res. 6, 115–122 (1998).

    CAS  Article  Google Scholar 

  15. Gorbsky, G.J. Bioessays 19, 193–197 (1997).

    CAS  Article  Google Scholar 

  16. Martineau, S., Andreassen, P.R. & Margolis, R.L. J. Cell Biol. 131, 191– 205 (1995).

    Article  Google Scholar 

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We thank W. Earnshaw, T. Yen and J. Harrington for anti–CENP antibodies. This work was supported by NIH grants HG00107 and HD32111 to H.F.W.

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Correspondence to Huntington F. Willard.

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Sullivan, B., Willard, H. Stable dicentric X chromosomes with two functional centromeres. Nat Genet 20, 227–228 (1998).

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