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Linkage between sexual orientation and chromosome Xq28 in males but not in females

Nature Genetics volume 11, pages 248–256 (1995)Cite this article

Abstract

We have extended our analysis of the role of the long arm of the X chromosome (Xq28) in sexual orientation by DNA linkage analyses of two newly ascertained series of families that contained either two gay brothers or two lesbian sisters as well as heterosexual siblings. Linkage between the Xq28 markers and sexual orientation was detected for the gay male families but not for the lesbian families or for families that failed to meet defined inclusion criteria for the study of sex–linked sexual orientation. Our results corroborate the previously reported linkage between Xq28 and male homosexuality in selected kinships and suggest that this region contains a locus that influences individual variations in sexual orientation in men but not in women.

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Authors and Affiliations

  1. Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Stella Hu, Angela M. L. Pattatucci, Chavis Patterson, Lin Li & Dean H. Hamer

  2. Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, 80309, USA

    David W. Fulker & Stacey S. Cherny

  3. Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02139, USA

    Leonid Kruglyak

Authors
  1. Stella Hu
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  2. Angela M. L. Pattatucci
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  3. Chavis Patterson
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  4. Lin Li
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  5. David W. Fulker
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  6. Stacey S. Cherny
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  7. Leonid Kruglyak
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  8. Dean H. Hamer
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Hu, S., Pattatucci, A., Patterson, C. et al. Linkage between sexual orientation and chromosome Xq28 in males but not in females. Nat Genet 11, 248–256 (1995). https://doi.org/10.1038/ng1195-248

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  • DOI: https://doi.org/10.1038/ng1195-248

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