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Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

Nature Genetics volume 5, pages 279–282 (1993)Cite this article

Abstract

Hereditary colon cancer is caused by mutations in several different loci. The APC gene on chromosome 5 causing adenomatous polyposis coli represents a minority of the inherited colon cancer cases, while hereditary–non polyposis colon cancer (HNPCC) may cause five percent of all human colon cancer. One gene causing HNPCC was recently mapped to chromosome 2 but the same study also showed that at least one additional locus may cause HNPCC. We now present tight linkage between a polymorphic marker on the short arm of chromosome 3 and the disease locus, and find that these families also manifest signs of a general DNA replication disorder.

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Authors and Affiliations

  1. Department of Clinical Genetics, Karolinska Hospital, S-104 01, Stockholm, Sweden

    Annika Lindblom, Pia Tannergård, Barbro Werelius & Magnus Nordenskjöld

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  1. Annika Lindblom
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  2. Pia Tannergård
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  4. Magnus Nordenskjöld
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Lindblom, A., Tannergård, P., Werelius, B. et al. Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer. Nat Genet 5, 279–282 (1993). https://doi.org/10.1038/ng1193-279

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