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Convergent evolution of gene circuits

Nature Genetics volume 34, pages 264266 (2003) | Download Citation

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Abstract

Convergent evolution is a potent indicator of optimal design. We show here that convergent evolution occurs in genetic networks. Specifically, we show that multiple types of transcriptional regulation circuitry in Escherichia coli and the yeast Saccharomyces cerevisiae have evolved independently and not by duplication of one or a few ancestral circuits.

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Acknowledgements

G.C.C. is supported by the US Department of Energy's Computational Sciences Graduate Fellowship program, administered by the Krell Institute. A.W. would like to thank the US National Institutes of Health and the Santa Fe Institute for their support.

Author information

Affiliations

  1. Department of Biology, 167 Castetter Hall, The University of New Mexico, Albuquerque, New Mexico 87131, USA.

    • Gavin C Conant
    •  & Andreas Wagner

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Andreas Wagner.

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DOI

https://doi.org/10.1038/ng1181