Abstract
Convergent evolution is a potent indicator of optimal design. We show here that convergent evolution occurs in genetic networks. Specifically, we show that multiple types of transcriptional regulation circuitry in Escherichia coli and the yeast Saccharomyces cerevisiae have evolved independently and not by duplication of one or a few ancestral circuits.
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References
Futuyma, D.J. Evolutionary Biology 3rd edn. (Sinauer Associates, Sunderland, Massachusetts, 1998).
Stewart, C.-B., Schilling, J.W. & Wilson, A.C. Nature 330, 401–404 (1987).
Kornegay, J.R., Schilling, J.W. & Wilson, A.C. Mol. Biol. Evol. 11, 921–928 (1994).
Chen, L., DeVries, A.L. & Cheng, C.-H.C. Proc. Natl. Acad. Sci. USA 94, 3817–3822 (1997).
Lee, T.I. et al. Science 298, 799–804 (2002).
Milo, R. et al. Science 298, 824–827 (2002).
Shen-Orr, S.S., Milo, R., Mangan, S. & Alon, U. Nat. Genet. 31, 64–68 (2002).
Lynch, M. & Conery, J.S. Science 290, 1151–1155 (2000).
Altschul, S.F. et al. Nucleic Acids Res. 25, 3389–3402 (1997).
Wagner, A. Mol. Biol. Evol. 18, 1283–1292 (2001).
Dermitzakis, E.T. & Clark, A.G. Mol. Biol. Evol. 19, 1114–1121 (2002).
Wagner, A. Proc. Natl. Acad. Sci. USA 97, 6579–6584 (2000).
Stone, J.R. & Wray, G.A. Mol. Biol. Evol. 18, 1764–1770 (2001).
Ferea, T.L., Botstein, D., Brown, P.O. & Rosenzweig, R.F. Proc. Natl. Acad. Sci. USA 96, 9721–9726 (1999).
Gould, S.J. Wonderful Life: The Burgess Shale and the Nature of History (W.W. Norton, New York, 1989).
Acknowledgements
G.C.C. is supported by the US Department of Energy's Computational Sciences Graduate Fellowship program, administered by the Krell Institute. A.W. would like to thank the US National Institutes of Health and the Santa Fe Institute for their support.
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Conant, G., Wagner, A. Convergent evolution of gene circuits. Nat Genet 34, 264–266 (2003). https://doi.org/10.1038/ng1181
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DOI: https://doi.org/10.1038/ng1181
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