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Different noses for different people

Abstract

Of more than 1,000 human olfactory receptor genes, more than half seem to be pseudogenes. We investigated whether the most recent of these disruptions might still segregate with the intact form by genotyping 51 candidate genes in 189 ethnically diverse humans. The results show an unprecedented prevalence of segregating pseudogenes, identifying one of the most pronounced cases of functional population diversity in the human genome.

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Figure 1: The observed individual olfactory receptor genotypes in African American (a) and non-African (b) individuals.
Figure 2: Phenotype distribution for different ethnic groups.

References

  1. Glusman, G., Yanai, I., Rubin, I. & Lancet, D. Genome Res. 11, 685–702 (2001).

    CAS  Article  Google Scholar 

  2. Zhang, X. & Firestein, S. Nat. Neurosci. 5, 124–133 (2002).

    CAS  Article  Google Scholar 

  3. Young, J.M. et al. Hum. Mol. Genet. 11, 535–546 (2002).

    CAS  Article  Google Scholar 

  4. Gilad, Y., Man, O., Paabo, S. & Lancet, D. Proc. Natl. Acad. Sci. USA 100, 3324–3327 (2003).

    CAS  Article  Google Scholar 

  5. Ehlers, A. et al. Genome Res. 10, 1968–1978 (2000).

    CAS  Article  Google Scholar 

  6. Menashe, I., Man, O., Lancet, D. & Gilad, Y. Hum. Mol. Genet. 11, 1381–1390 (2002).

    CAS  Article  Google Scholar 

  7. Gilad, Y. & Lancet, D. Mol. Biol. Evol. 20, 307–314 (2003).

    CAS  Article  Google Scholar 

  8. Amoore, J.E. Ann. NY Acad. Sci. 237, 137–143 (1974).

    CAS  Article  Google Scholar 

  9. Whissell-Buechy, D. & Amoore, J.E. Nature 242, 271–273 (1973).

    CAS  Article  Google Scholar 

  10. Schoneberg, T., Schulz, A. & Gudermann, T. Rev. Physiol. Biochem. Pharmacol. 144, 143–227 (2002).

    CAS  PubMed  Google Scholar 

  11. Wysocki, C.J. & Beauchamp, G.K. Proc. Natl. Acad. Sci. USA 81, 4899–4902 (1984).

    CAS  Article  Google Scholar 

  12. Yeager, M. & Hughes, A.L. Immunol. Rev. 167, 45–58 (1999).

    CAS  Article  Google Scholar 

  13. Barron, K.S. & Robinson, M.A. Hum. Immunol. 40, 17–19 (1994).

    CAS  Article  Google Scholar 

  14. Harrison, P.M. et al. Genome Res. 12, 272–280 (2002).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

We thank M. Przeworski for helpful discussions. D.L. holds the Ralph and Lois Silver Chair in Human Genomics. This work was supported by the Crown Human Genome Center at the Weizmann Institute of Science and by an Israel Ministry of Science grant to the National Laboratory for Genome Infrastructure.

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Correspondence to Doron Lancet.

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Menashe, I., Man, O., Lancet, D. et al. Different noses for different people. Nat Genet 34, 143–144 (2003). https://doi.org/10.1038/ng1160

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