Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

Deficiency of Mbd2 suppresses intestinal tumorigenesis


Gene silencing through de novo methylation of CpG island promoters contributes to cancer. We find that Mbd2, which recruits co-repressor complexes to methylated DNA, is essential for efficient tumorigenesis in the mouse intestine. As Mbd2-deficient mice are viable and fertile, their resistance to intestinal cancer may be of therapeutic relevance.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Deficiency of Mbd2 increases lifespan of ApcMin/+ mice in a dose-dependent manner.
Figure 2: Tumors of Mbd2−/− mice have lower incidence, are smaller in size and have an altered intestinal distribution.

Similar content being viewed by others


  1. Laird, P.W. et al. Cell 81, 197–205 (1995).

    Article  CAS  Google Scholar 

  2. Eads, C.A., Nickel, A.E. & Laird, P.W. Cancer Res. 62, 1296–1299 (2002).

    CAS  PubMed  Google Scholar 

  3. Ng, H.-H. et al. Nat. Genet. 23, 58–61 (1999).

    Article  CAS  Google Scholar 

  4. Hutchins, A. et al. Mol. Cell 10, 81–91 (2002).

    Article  CAS  Google Scholar 

  5. Su, L.K. et al. Science 256, 668–670 (1992).

    Article  CAS  Google Scholar 

  6. Hendrich, B., Guy, J., Ramsahoye, B., Wilson, V.A. & Bird, A. Genes Dev. 15, 710–723 (2001).

    Article  CAS  Google Scholar 

  7. Dietrich, W.F. et al. Cell 75, 631–639 (1993).

    Article  CAS  Google Scholar 

  8. Bhattacharya, S.K., Ramchandani, S., Cervoni, N. & Szyf, M. Nature 397, 579–583 (1999).

    Article  CAS  Google Scholar 

  9. Santos, F., Hendrich, B., Reik, W. & Dean, W. Dev. Biol. 241, 172–182 (2002).

    Article  CAS  Google Scholar 

  10. Esteller, M. et al. Cancer Res. 60, 4366–4371 (2000).

    CAS  PubMed  Google Scholar 

  11. Luongo, C., Moser, A.R., Gledhill, S. & Dove, W.F. Cancer Res. 54, 5947–5952 (1994).

    CAS  PubMed  Google Scholar 

  12. Magdinier, F. & Wolffe, A.P. Proc. Natl. Acad. Sci. USA 98, 4990–4995 (2001).

    Article  CAS  Google Scholar 

  13. Lin, X. & Nelson, W.G. Cancer Res. 63, 498–504 (2003).

    CAS  PubMed  Google Scholar 

  14. Billard, L.M., Magdinier, F., Lenoir, G.M., Frappart, L. & Dante, R. Oncogene 21, 2704–2712 (2002).

    Article  CAS  Google Scholar 

  15. Slack, A. et al. J. Gene Med. 4, 381–389 (2002).

    Article  CAS  Google Scholar 

Download references


We thank K. Wilson, N. Hill and D. Scarborough for technical assistance. This work was funded by the Wellcome Trust and Cancer Research UK. J.B. is supported by the European Union. A.R.C. is a Royal Society Research Fellow.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Adrian Bird.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sansom, O., Berger, J., Bishop, S. et al. Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nat Genet 34, 145–147 (2003).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing