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Genome-wide association studies coming of age in rice

A new study reports the next-generation sequencing of 517 rice genomes, each to approximately onefold coverage. By leveraging sequence information across rice lines and by imputing missing genotypes, a haplotype map (HapMap) was constructed and used for genome-wide association studies in this major crop.

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Figure 1: Constructing a rice HapMap for GWAS with low-fold sequencing.

Marina Corral


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Correspondence to Richard M Clark.

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Clark, R. Genome-wide association studies coming of age in rice. Nat Genet 42, 926–927 (2010).

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