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Building in resistance to endothelial cell death

A new study in zebrafish shows that Birc2, a member of the inhibitor of apoptosis (IAP) family, is required for endothelial cell survival. This discovery highlights an important in vivo function of this molecule and suggests potential avenues for the development of new antiangiogenic therapies.

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Figure 1: Birc2 regulates endothelial cell survival.

Kim Caesar

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Mazzone, M., de Almodovar, C. & Carmeliet, P. Building in resistance to endothelial cell death. Nat Genet 39, 1308–1309 (2007). https://doi.org/10.1038/ng1107-1308

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