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How the dog got its spots

Differences among dog breeds provide unique opportunities for studying the genetics of behavior, morphology and complex disease. Two new studies demonstrate how the unique evolutionary history of domestic dogs is particularly well suited to analysis by genome-wide association.

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Figure 1: Genome-wide association in domestic dogs.

References

  1. Anonymous. J. Hered. 36, 142 (1945).

  2. Wright, S. J. Hered. 9, 87–90 (1918).

    Article  Google Scholar 

  3. Lindblad-Toh, K. et al. Nature 438, 803–819 (2005).

    Article  CAS  Google Scholar 

  4. Karlsson, E.K. et al. Nat. Genet. 39, 1321–1328 (2007).

    Article  CAS  Google Scholar 

  5. Salmon Hillbertz, N.H.C. et al. Nat. Genet. 39, 1318–1320 (2007).

    Article  CAS  Google Scholar 

  6. International HapMap Consortium. Nature 437, 1299–1320 (2005).

  7. Sutter, N.B. et al. Genome Res. 14, 2388–2396 (2004).

    Article  CAS  Google Scholar 

  8. Goding, C.R. Genes Dev. 14, 1712–1728 (2000).

    CAS  PubMed  Google Scholar 

  9. Cattanach, B. J. Small Anim. Pract. 40, 193–200 (1999).

    Article  CAS  Google Scholar 

  10. Ostrander, E.A. & Wayne, R.K. Genome Res. 15, 1706–1716 (2005).

    Article  CAS  Google Scholar 

Download references

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Barsh, G. How the dog got its spots. Nat Genet 39, 1304–1306 (2007). https://doi.org/10.1038/ng1107-1304

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