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R-spondin1 tips the balance in sex determination

Female-to-male sex reversal is an extremely rare and puzzling phenomenon. A new study identifies mutations in the gene encoding R-spondin1 in XX sex-reversed individuals and suggests that antagonistic pathways in the bipotential gonad regulate sex determination.

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Capel, B. R-spondin1 tips the balance in sex determination. Nat Genet 38, 1233–1234 (2006).

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