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Bone talk

Two new reports extend the functions of DMP1, a bone matrix protein involved in mineralization, to phosphate regulation. These discoveries provide insight into the mechanism by which bone may coordinate systemic phosphate balance with the needs of mineralizing bone.

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Figure 1: Potential roles of DMP1 in osteoblasts and osteocytes.

Kim Caesar

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Schiavi, S. Bone talk. Nat Genet 38, 1230–1231 (2006). https://doi.org/10.1038/ng1106-1230

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