Figure 1: Schematic depiction of the Fanconi anemia DNA repair pathway. | Nature Genetics

Figure 1: Schematic depiction of the Fanconi anemia DNA repair pathway.

From: A new gene on the X involved in Fanconi anemia

Figure 1

DNA damage activates the complex of Fanconi anemia–associated proteins FANCA, FANCB, FANCE, FANCF, FANCG and FANCL1. FANCL5 is a ubiquitin ligase that probably causes the ubiquitination of FANCD2. This protein, together with another Fanconi anemia–associated protein, BRCA2 and RAD51, is involved in the repair of DNA damage.