Retroviruses make up a large proportion of the mammalian genome. A new study shows that an mRNA nuclear export receptor can act as a modifier of endogenous retrovirus insertion mutations by interacting with the mutated pre-mRNA.
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Muotri, A., Gage, F. Vibrating in the background. Nat Genet 35, 205–207 (2003). https://doi.org/10.1038/ng1103-205