It is well known that the efficacy of certain drugs varies from individual to individual, depending in part on variation in the genes that encode drug metabolizing enzymes. Whereas ethnic and geographic differences are commonly used to classify drug response, new results show that more accurate and robust genetic clusters—identified by genotyping a modest number of neutral markers—can be inferred with no prior knowledge of ethnicity. Such an approach may eventually become a part of drug evaluation and clinical practice.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
McLeod, H.L & Evans, W.E. Annu. Rev. Pharmacol. Toxicol. 41,101–121 (2001).
Ameyaw, M.M. et al. Pharmacogenetics 11, 217–221 (2001).
Xie, H.G., Kim, R.B., Wood, A.J. & Stein, C.M. Annu. Rev. Pharmacol. Toxicol. 41, 815–850 (2001).
McLeod, H.L. et al. Pharmacogenetics 9, 773–776 (1999).
Wilson, J.F. et al. Nature Genet. 29, 265–269 (2001).
McLeod, H.L., Krynetski, E.Y., Relling, M.V. & Evans, W.E. Leukemia 14, 567–572 (2000).
Evans, W.E. & Relling, M.V. Science 286, 487–491 (1999).
Exner, D.V., Dries, D.L., Domanski, M.J. & Cohn, J.N. N. Engl. J. Med. 344, 1351–1357 (2001).
McLeod, H.L. N. Engl. J. Med. 345, 766–767 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McLeod, H. Pharmacogenetics: more than skin deep. Nat Genet 29, 247–248 (2001). https://doi.org/10.1038/ng1101-247
Issue Date:
DOI: https://doi.org/10.1038/ng1101-247
This article is cited by
-
Personalized Pharmacotherapy: Genotypes, Biomarkers, and Beyond
Clinical Pharmacology & Therapeutics (2009)