Normal telomere lengths found in cloned cattle

Abstract

Success of cloning using adult somatic cells has been reported in sheep1, mice2,3 and cattle4,5,6,7. The report that `Dolly'8 the sheep, the first clone from an adult mammal, inherited shortened telomeres from her cell donor and that her telomeres were further shortened by the brief culture of donor cells has raised serious scientific and public concerns about the `genetic age' and potential developmental problems of cloned animals. This observation was challenged by a recent report9 that showed calves cloned from fetal cells have longer telomeres than their age-matched controls. The question remains whether Dolly's short telomeres were an exception or a general fact, which would differ from the telomeres of fetal-derived clones.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Telomere length analyses.
Figure 2: Relative telomerase activity in embryos produced by nuclear transfer (NT) versus in vitro fertilization (IVF).

References

  1. 1

    Wilmut, I., Schnieke, A.E., McWhir, J., Kind, A.J. & Campbell, K.H.S. Nature 385, 810–813 (1997).

    CAS  Article  Google Scholar 

  2. 2

    Wakayama, T., Perry, A.C.F., Zuccotti, M., Johnson, K.R. & Yanagimachi, R. Nature 394, 369–374 (1998).

    CAS  Article  Google Scholar 

  3. 3

    Rideout, W.M. III et al. Nature Genet. 24, 109–110 (2000).

    CAS  Article  Google Scholar 

  4. 4

    Kato, Y. et al. Science 282, 2095–2098 (1998).

    CAS  Article  Google Scholar 

  5. 5

    Renard, J.-P. et al. Lancet 353, 1489–1491 (1998).

    Article  Google Scholar 

  6. 6

    Wells, D.N., Misica, P.M. & Tervit, H.R. Biol. Reprod. 60, 996–1005 (1999).

    CAS  Article  Google Scholar 

  7. 7

    Kubota, C. et al. Proc. Natl Acad. Sci. USA 97, 990–995 (2000).

    CAS  Article  Google Scholar 

  8. 8

    Shiels, P. et al. Nature 399, 316–317 (1999).

    CAS  Article  Google Scholar 

  9. 9

    Lanza, R.P. et al. Science 288, 665–669 (2000).

    CAS  Article  Google Scholar 

  10. 10

    Harley, C.B., Futcher, A.B. & Greider, C.W. Nature 345, 458–460 (1990).

    CAS  Article  Google Scholar 

  11. 11

    Zhu, L. et al. Proc. Natl Acad. Sci. USA 95, 8648–8653 (1998).

    CAS  Article  Google Scholar 

  12. 12

    Bodnar, A.G. et al. Science 279, 349–352 (1998).

    CAS  Article  Google Scholar 

  13. 13

    Betts, D.H. & King, W.A. Dev. Genet. 25, 397–403 (1999).

    CAS  Article  Google Scholar 

  14. 14

    Xu, J. & Yang, X. Biol. Reprod . 63, 1124–1128 (2000).

    CAS  Article  Google Scholar 

  15. 15

    Kozik, A., Bradbury, E.M. & Zalensky, A. Mol. Reprod. Dev. 51, 98–104 (1998).

    CAS  Article  Google Scholar 

  16. 16

    Wakayama, T. et al. Nature 407, 318–319 (2000).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

We thank M. Barber and M. Taneja for cell culture and tissue biopsies, and R. Foote for critical reading of the manuscript. This research was supported in part by a grant from the Connecticut Innovations, Inc.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Xiangzhong Yang.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Tian, X., Xu, J. & Yang, X. Normal telomere lengths found in cloned cattle. Nat Genet 26, 272–273 (2000). https://doi.org/10.1038/81559

Download citation

Further reading

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing