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A frameshift mutation in MC4R associated with dominantly inherited human obesity

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Figure 1: A frameshift mutation in MC4R is associated with dominantly inherited obesity.
Figure 2: Auxology for subjects heterozygous for a frameshift mutation in MC4R.


  1. Mountjoy, K.G. & Wong, J. Mol. Cell Endocrinol. 128 , 171–177 (1997).

    Article  CAS  Google Scholar 

  2. Fan, W. et al. Nature 385, 165–168 (1997).

    Article  CAS  Google Scholar 

  3. Huszar, D. et al. Cell 88, 131–141 (1997).

    Article  CAS  Google Scholar 

  4. Lu, D. et al. Nature 371, 799–802 (1994).

    Article  CAS  Google Scholar 

  5. Ollmann, M. M. et al. Science 278, 135– 138 (1997).

    Article  CAS  Google Scholar 

  6. Krude, H. et al. Nature Genet. 19, 155– 157 (1998).

    Article  CAS  Google Scholar 

  7. Jackson, R.S. et al. Nature Genet. 16, 303– 306 (1997).

    Article  CAS  Google Scholar 

  8. Shenker, A. Baillieres Clin. Endocrinol. Metab. 9, 427– 451 (1995).

    Article  CAS  Google Scholar 

  9. Montague, C.T. & Farooqi, I.S. et al. Nature 387, 903–908 (1997).

    Article  CAS  Google Scholar 

  10. Strobel, A. et al. Nature Genet. 18, 213– 215 (1998).

    Article  CAS  Google Scholar 

  11. Clement, K. et al. Nature 392, 398–401 (1998).

    Article  CAS  Google Scholar 

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We thank G. Cook for her help in establishing the patient cohort and the many clinicians who have referred patients to us. S.O.R. & I.S.F are supported by the Wellcome Trust.

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Correspondence to Stephen O'Rahilly.

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Yeo, G., Farooqi, I., Aminian, S. et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 20, 111–112 (1998).

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