A frameshift mutation in MC4R associated with dominantly inherited human obesity

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Figure 1: A frameshift mutation in MC4R is associated with dominantly inherited obesity.
Figure 2: Auxology for subjects heterozygous for a frameshift mutation in MC4R.

References

  1. 1

    Mountjoy, K.G. & Wong, J. Mol. Cell Endocrinol. 128 , 171–177 (1997).

  2. 2

    Fan, W. et al. Nature 385, 165–168 (1997).

  3. 3

    Huszar, D. et al. Cell 88, 131–141 (1997).

  4. 4

    Lu, D. et al. Nature 371, 799–802 (1994).

  5. 5

    Ollmann, M. M. et al. Science 278, 135– 138 (1997).

  6. 6

    Krude, H. et al. Nature Genet. 19, 155– 157 (1998).

  7. 7

    Jackson, R.S. et al. Nature Genet. 16, 303– 306 (1997).

  8. 8

    Shenker, A. Baillieres Clin. Endocrinol. Metab. 9, 427– 451 (1995).

  9. 9

    Montague, C.T. & Farooqi, I.S. et al. Nature 387, 903–908 (1997).

  10. 10

    Strobel, A. et al. Nature Genet. 18, 213– 215 (1998).

  11. 11

    Clement, K. et al. Nature 392, 398–401 (1998).

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Acknowledgements

We thank G. Cook for her help in establishing the patient cohort and the many clinicians who have referred patients to us. S.O.R. & I.S.F are supported by the Wellcome Trust.

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Correspondence to Stephen O'Rahilly.

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