Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL

Abstract

After V(D)J-mediated translocations, signal joints are retained on one of the derivative chromosomes. We report here that such signal joints are highly reactive and constitute unstable genomic elements with potential oncogenic properties.

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Figure 1: Two-step model of t(7;9)(q34;q32) translocation and TAL2 activation.
Figure 2: t(7;9)(q34;q32) der(9) breakpoints.

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Acknowledgements

We thank P. Ferrier, A.W. Langerak, J.J.M van Dongen and F. McBlane for comments and discussions and E. Hayden for help with the statistical analysis. This work was supported by the Center of Molecular Medicine of the Austrian Academy of Sciences.

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Correspondence to Bertrand Nadel.

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The authors declare no competing financial interests.

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Marculescu, R., Vanura, K., Le, T. et al. Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL. Nat Genet 33, 342–344 (2003). https://doi.org/10.1038/ng1092

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