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Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL

Nature Genetics volume 33, pages 342–344 (2003)Cite this article

Abstract

After V(D)J-mediated translocations, signal joints are retained on one of the derivative chromosomes. We report here that such signal joints are highly reactive and constitute unstable genomic elements with potential oncogenic properties.

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Figure 1: Two-step model of t(7;9)(q34;q32) translocation and TAL2 activation.
Figure 2: t(7;9)(q34;q32) der(9) breakpoints.

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Acknowledgements

We thank P. Ferrier, A.W. Langerak, J.J.M van Dongen and F. McBlane for comments and discussions and E. Hayden for help with the statistical analysis. This work was supported by the Center of Molecular Medicine of the Austrian Academy of Sciences.

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Author notes

  1. Rodrig Marculescu

    Present address: Department of Laboratory Medicine, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria

  2. Bertrand Nadel

    Present address: Centre d'Immunologie CNRS-INSERM de Marseille-Luminy, Parc Scientifique de Luminy, case 906, 13288, Marseille, Cedex 9, France

  3. Rodrig Marculescu and Katrina Vanura: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Internal Medicine I, Division of Hematology, University of Vienna, Währinger Gürtel 18-20, Vienna, A-1090, Austria

    Rodrig Marculescu, Katrina Vanura, Trang Le, Ulrich Jäger & Bertrand Nadel

  2. Center of Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

    Katrina Vanura, Ulrich Jäger & Bertrand Nadel

  3. Department of Surgery, University of Vienna, Vienna, Austria

    Paul Simon

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  1. Rodrig Marculescu
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Correspondence to Bertrand Nadel.

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Marculescu, R., Vanura, K., Le, T. et al. Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL. Nat Genet 33, 342–344 (2003). https://doi.org/10.1038/ng1092

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