Yoshida, S., Goto, Y., Mizuguchi, Y., Nomoto, K. & Skamene, E. Genetic control of natural resistance in mouse macrophages regulating intracellular Legionella pneumophila multiplication in vitro. Infect. Immun. 59, 428–432 (1991).
Diez, E. et al. Genetic and physical mapping of the mouse host resistance locus Lgn1. Mamm. Genome 8, 682–685 (1997).
Growney, J.D. & Dietrich, W.F. High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis. Genome Res. 10, 1158–1171 (2000).
McDade, J.E. et al. Legionnaires' disease: isolation of a bacterium and demonstration of its role in other respiratory disease. N. Engl. J. Med. 297, 1197–1203 (1977).
Horwitz, M.A. & Silverstein, S.C. Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes. J. Clin. Invest. 66, 441–450 (1980).
Swanson, M.S. & Isberg, R.R. Association of Legionella pneumophila with the macrophage endoplasmic reticulum. Infect. Immun. 63, 3609–3620 (1995).
Yamamoto, Y., Klein, T.W., Newton, C.A. & Friedman, H. Interaction of Legionella pneumophila with peritoneal macrophages from various mouse strains. Adv. Exp. Med. Biol. 239, 89–98 (1988).
Yamamoto, Y., Klein, T.W., Newton, C.A., Widen, R. & Friedman, H. Growth of Legionella pneumophila in thioglycolate-elicited peritoneal macrophages from A/J mice. Infect. Immun. 56, 370–375 (1988).
Beckers, M.C., Yoshida, S., Morgan, K., Skamene, E. & Gros, P. Natural resistance to infection with Legionella pneumophila: chromosomal localization of the Lgn1 susceptibility gene. Mamm. Genome 6, 540–545 (1995).
Scharf, J.M. et al. The mouse region syntenic for human spinal muscular atrophy lies within the Lgn1 critical interval and contains multiple copies of Naip exon 5. Genomics 38, 405–417 (1996).
Endrizzi, M.G., Hadinoto, V., Growney, J.D., Miller, W. & Dietrich, W.F. Genomic sequence analysis of the mouse Naip gene array. Genome Res. 10, 1095–1102 (2000).
Diez, E., Yaraghi, Z., MacKenzie, A. & Gros, P. The neuronal apoptosis inhibitory protein (Naip) is expressed in macrophages and is modulated after phagocytosis and during intracellular infection with Legionella pneumophila. J. Immunol. 164, 1470–1477 (2000).
Growney, J.D., Scharf, J.M., Kunkel, L.M. & Dietrich, W.F. Evolutionary divergence of the mouse and human Lgn1/SMA repeat structures. Genomics 64, 62–81 (2000).
Holcik, M. et al. The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid- induced injury. Proc. Natl. Acad. Sci. USA 97, 2286–2290 (2000).
Wright, E.K. et al. Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Curr. Biol. 13, in the press (2003).
Roy, N. et al. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell 80, 167–178 (1995).
Somerville, M.J. et al. Clinical application of the molecular diagnosis of spinal muscular atrophy: deletions of neuronal apoptosis inhibitor protein and survival motor neuron genes. Am. J. Med. Genet. 69, 159–165 (1997).
Haider, M.Z., Moosa, A., Dalal, H., Habib, Y. & Reynold, L. Gene deletion patterns in spinal muscular atrophy patients with different clinical phenotypes. J. Biomed. Sci. 8, 191–196 (2001).
Liston, P. et al. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 379, 349–353 (1996).
Hozak, R.R., Manji, G.A. & Friesen, P.D. The BIR motifs mediate dominant interference and oligomerization of inhibitor of apoptosis Op-IAP. Mol. Cell. Biol. 20, 1877–1885 (2000).
Wu, G. et al. Structural basis of IAP recognition by Smac/DIABLO. Nature 408, 1008–1012 (2000).
Koonin, E.V. & Aravind, L. The NACHT family—a new group of predicted NTPases implicated in apoptosis and MHC transcription activation. Trends Biochem. Sci. 25, 223–224 (2000).
Perrelet, D. et al. IAP family proteins delay motoneuron cell death in vivo. Eur. J. Neurosci. 12, 2059–2067 (2000).
Maier, J.K. et al. The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7. J. Neurosci. 22, 2035–2043 (2002).
Gao, L.Y. & Abu Kwaik, Y. Apoptosis in macrophages and alveolar epithelial cells during early stages of infection by Legionella pneumophila and its role in cytopathogenicity. Infect. Immun. 67, 862–870 (1999).
Muller, A., Hacker, J. & Brand, B.C. Evidence for apoptosis of human macrophage-like HL-60 cells by Legionella pneumophila infection. Infect. Immun. 64, 4900–4906 (1996).
Watarai, M. et al. Legionella pneumophila is internalized by a macropinocytotic uptake pathway controlled by the Dot/Icm system and the mouse Lgn1 locus. J. Exp. Med. 194, 1081–1096 (2001).
Yaraghi, Z., Korneluk, R.G. & MacKenzie, A. Cloning and characterization of the multiple murine homologues of NAIP (neuronal apoptosis inhibitory protein). Genomics 51, 107–113 (1998).
Endrizzi, M. et al. Comparative sequence analysis of the mouse and human Lgn1/SMA interval. Genomics 60, 137–151 (1999).