Alzheimer’s disease beyond APOE

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Two genome-wide association studies together report three new susceptibility loci for late-onset Alzheimer’s disease. CLU, PICALM and CR1 may be involved in amyloid-β clearance from the brain.

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Figure 1: The balance between APP processing and clearance in a model of AD pathogenesis.

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Correspondence to Michael A van Es or Leonard H van den Berg.

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