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Kidney disease and African ancestry

Mapping by admixture linkage disequilibrium (MALD) leverages differences in disease frequencies among ancestry groups to map disease-susceptibility loci on the basis of genetic admixture. Two new studies use MALD to identify variation at the MYH9 locus as a major factor for the increased risk of nondiabetic kidney disease in African Americans.

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Figure 1: Sequential electron micrographs (EM) of a glomerulus showing glomerular capillary loops covered by podocytes and their interdigitating contractile extensions known as foot processes.


  1. Freedman, B.I. J. Am. Soc. Nephrol. 14, S192–S194 (2003).

    Article  CAS  Google Scholar 

  2. Price, D.A. & Crook, E.D. J. Natl. Med. Assoc. 94, 16S–27S (2002).

    PubMed  PubMed Central  Google Scholar 

  3. Kopp, J.B. et al. Nat. Genet. 40, 1175–1184 (2008).

    Article  CAS  Google Scholar 

  4. Kao, W.H.L. et al. Nat. Genet. 40, 1185–1192 (2008).

    Article  CAS  Google Scholar 

  5. Patterson, N. et al. Am. J. Hum. Genet. 74, 979–1000 (2004).

    Article  CAS  Google Scholar 

  6. Zhu, X., Tang, H. & Risch, N. Adv. Genet. 60, 547–569 (2008).

    Article  Google Scholar 

  7. Winn, M.P. et al. Science 308, 1801–1804 (2005).

    Article  CAS  Google Scholar 

  8. Boute, N. et al. Nat. Genet. 24, 349–354 (2000).

    Article  CAS  Google Scholar 

  9. Kaplan, J.M. et al. Nat. Genet. 24, 251–256 (2000).

    Article  CAS  Google Scholar 

  10. Heath, K.E. et al. Am. J. Hum. Genet. 69, 1033–1045 (2001).

    Article  CAS  Google Scholar 

  11. Asanuma, K. et al. J. Clin. Invest. 115, 1188–1198 (2005).

    Article  CAS  Google Scholar 

  12. Drenckhahn, D. & Franke, R.P. Lab. Invest. 59, 673–682 (1988).

    CAS  PubMed  Google Scholar 

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Pollak, M. Kidney disease and African ancestry. Nat Genet 40, 1145–1146 (2008).

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