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Kidney disease and African ancestry

Mapping by admixture linkage disequilibrium (MALD) leverages differences in disease frequencies among ancestry groups to map disease-susceptibility loci on the basis of genetic admixture. Two new studies use MALD to identify variation at the MYH9 locus as a major factor for the increased risk of nondiabetic kidney disease in African Americans.

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Figure 1: Sequential electron micrographs (EM) of a glomerulus showing glomerular capillary loops covered by podocytes and their interdigitating contractile extensions known as foot processes.

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Pollak, M. Kidney disease and African ancestry. Nat Genet 40, 1145–1146 (2008). https://doi.org/10.1038/ng1008-1145

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  • DOI: https://doi.org/10.1038/ng1008-1145

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