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Kidney disease and African ancestry

Nature Genetics volume 40, pages 1145–1146 (2008)Cite this article

Mapping by admixture linkage disequilibrium (MALD) leverages differences in disease frequencies among ancestry groups to map disease-susceptibility loci on the basis of genetic admixture. Two new studies use MALD to identify variation at the MYH9 locus as a major factor for the increased risk of nondiabetic kidney disease in African Americans.

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Figure 1: Sequential electron micrographs (EM) of a glomerulus showing glomerular capillary loops covered by podocytes and their interdigitating contractile extensions known as foot processes.

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Authors and Affiliations

  1. Martin R. Pollak is in the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. mpollak@rics.bwh.harvard.edu,

    Martin R Pollak

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  1. Martin R Pollak
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Pollak, M. Kidney disease and African ancestry. Nat Genet 40, 1145–1146 (2008). https://doi.org/10.1038/ng1008-1145

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