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How microRNAs choose their targets

Nature Genetics volume 39, pages 1191–1192 (2007)Cite this article

The growing list of known microRNAs is only as useful as our ability to identify the mRNA targets they control. A new study stresses the role of messenger RNA structure in microRNA target recognition and suggests that binding of the RNA-induced silencing complex is largely controlled by the thermodynamics of RNA-RNA interactions.

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Figure 1: Binding of a microRNA to a messenger RNA is depicted as a two-step process.

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  1. Ivo L. Hofacker is at the Institute for Theoretical Chemistry, University of Vienna, Währingerstraße 17, A-1090 Wien, Austria. ivo@tbi.univie.ac.at,

    Ivo L Hofacker

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  1. Ivo L Hofacker
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Hofacker, I. How microRNAs choose their targets. Nat Genet 39, 1191–1192 (2007). https://doi.org/10.1038/ng1007-1191

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