Optimally positioned crossovers facilitate the proper segregation of chromosomes in meiosis. A new study in yeast implicates the spindle checkpoint in the rescue of crossovers that occur too distant from the centromere, possibly shedding light on the origins of nondisjunction in higher organisms.
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Hassold, T., Hunt, P. Rescuing distal crossovers. Nat Genet 39, 1187–1188 (2007). https://doi.org/10.1038/ng1007-1187
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DOI: https://doi.org/10.1038/ng1007-1187