Groups of interacting proteins define functional modules that govern a cell's activity. A new study suggests that specific interaction motifs and their constituents are highly conserved across species, identifying potential functional modules used in the evolutionary process.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Interlog protein network: an evolutionary benchmark of protein interaction networks for the evaluation of clustering algorithms
BMC Bioinformatics Open Access 05 October 2015
-
A methodology for detecting the orthology signal in a PPI network at a functional complex level
BMC Bioinformatics Open Access 25 June 2012
-
Phylogenetic analysis of modularity in protein interaction networks
BMC Bioinformatics Open Access 14 October 2009
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Wuchty, S. et al. Nat. Genet. 35, 176–179 (2003).
Barabasi, A.-L. Linked (Perseus, Cambridge, Massachusetts, 2002).
Dorogovtsev, S.N. & Mendes, J.F.F. Evolution of Networks (Oxford University Press, Oxford, 2003).
Hodgman, T.C. Bioinformatics 16, 10–15 (2000).
Oltvai, Z.N. & Barabasi, A.-L. Science 298, 763–764 (2002).
Ravasz, E. et al. Science 297, 1551–1555 (2002).
Hartwell, L.H. et al. Nature 402, C47–C52 (1999).
Milo, R. et al. Science 298, 824–827 (2002).
Vazquez, A. et al. Complexus 1, 38–42 (2003).
Pastor-Satorras, R. et al. J. Theor. Biol. 222, 199–210 (2003).
Hishigaki, H. et al. Yeast 18, 523–531 (2001).
Vazquez, A. et al. Nat. Biotechnol. 21, 697–700 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vespignani, A. Evolution thinks modular. Nat Genet 35, 118–119 (2003). https://doi.org/10.1038/ng1003-118
Issue Date:
DOI: https://doi.org/10.1038/ng1003-118
This article is cited by
-
Statistical properties of complex network for seismicity using depth-incorporated influence radius
Acta Geophysica (2019)
-
Stability of Control Networks in Autonomous Homeostatic Regulation of Stem Cell Lineages
Bulletin of Mathematical Biology (2018)
-
Interlog protein network: an evolutionary benchmark of protein interaction networks for the evaluation of clustering algorithms
BMC Bioinformatics (2015)
-
Integrative approaches for finding modular structure in biological networks
Nature Reviews Genetics (2013)
-
A methodology for detecting the orthology signal in a PPI network at a functional complex level
BMC Bioinformatics (2012)
