The visual pigment rhodopsin consists of the apoprotein opsin and the retinoid chromophore 11-cis-retinal. Visual signaling is triggered upon photoisomerization of 11-cis-retinal into all-trans-retinal. A new study shows that visual signaling by opsin in the absence of chromophore is a pathogenetic mechanism of visual cell loss.
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References
Portera-Cailliau, C., Sung, C.H., Nathans, J. & Adler, R. Proc. Natl. Acad. Sci. USA 91, 974–978 (1994).
Reme, C.E., Grimm, C., Hafezi, F., Marti, A. & Wenzel, A. Prog. Retin. Eye Res. 17, 443–464 (1998).
Woodruff, M.L. et al. Nat. Genet. 34, 158–164 (2003).
Pugh, E.N., Jr., Nikonov, S. & Lamb, T.D. Curr. Opin. Neurobiol. 9, 410–418 (1999).
Redmond, T.M. et al. Nat. Genet. 20, 344–351 (1998).
Seeliger, M.W. et al. Nat. Genet. 29, 70–74 (2001).
Zhukovsky, E.A., Robinson, P.R. & Oprian, D.D. Science 251, 558–560 (1991).
Cornwall, M.C. & Fain, G.L. J. Physiol. 480 (Pt 2), 261–279 (1994).
Sieving, P.A. et al. J. Neurosci. 21, 5449–5460 (2001).
Van Hooser, J.P. et al. J. Biol. Chem. 277, 19173–19182 (2002).
Jin, S., Cornwall, M.C. & Oprian, D.D. Nat. Neurosci. 6, 731–735 (2003).
Sokolov, M. et al. Neuron 34, 95–106 (2002).
Grimm, C. et al. Nat. Genet. 25, 63–66 (2000).
Seifert, R. & Wenzel-Seifert, K. Naunyn Schmiedebergs Arch. Pharmacol. 366, 381–416 (2002).
Hao, W. et al. Nat. Genet. 32, 254–260 (2002).
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Remé, C., Wenzel, A. The dangers of seeing light in the dark. Nat Genet 35, 115–116 (2003). https://doi.org/10.1038/ng1003-115
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DOI: https://doi.org/10.1038/ng1003-115
