What is the best way to identify regulatory DNA sequences such as enhancers, promoters, insulators and silencers? A new study shows that specific binding by a coactivator protein identifies enhancers that are invisible to common detection methods based on evolutionary constraint.
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Hardison, R. Variable evolutionary signatures at the heart of enhancers. Nat Genet 42, 734–735 (2010). https://doi.org/10.1038/ng0910-734
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DOI: https://doi.org/10.1038/ng0910-734
