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Putting a finger on the switch

Nature Genetics volume 42, pages 733–734 (2010)Cite this article

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The transition from fetal to adult β-like globin expression is a key step in the maturation of the red blood cell lineage. Two new studies show that the KLF1 zinc finger protein uses direct and indirect means to regulate the final switch from fetal to adult globin expression and that monoallelic loss of KLF1 expression leads to persistence of fetal hemoglobin.

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Figure 1: KLF1 regulates globin switching.

References

  1. Stamatoyannopoulos, G. & Grosveld, F. in The Molecular Basis of Blood Diseases 3rd edn. (W.B. Saunders Company, Philadelphia, 2001).

    Google Scholar 

  2. Weatherall, D.J. in The Molecular Basis of Blood Diseases 3rd edn. (W.B. Saunders Company, Philadelphia, 2001).

    Google Scholar 

  3. Borg, J. et al. Nat. Genet. 42, 801–805 (2010).

    Article  CAS  Google Scholar 

  4. Zhou, D., Liu, K., Sun, C.-W., Pawlik, K.M. & Townes, T.M. Nat. Genet. 42, 742–744 (2010).

    Article  CAS  Google Scholar 

  5. Bieker, J.J. in Transcription Factors: Normal and Malignant Development of Blood Cells (Wiley-Liss, New York, 2001).

    Google Scholar 

  6. Perkins, A. Int. J. Biochem. Cell Biol. 31, 1175–1192 (1999).

    Article  CAS  Google Scholar 

  7. Singleton, B.K., Burton, N.M., Green, C., Brady, R.L. & Anstee, D.J. Blood 112, 2081–2088 (2008).

    Article  CAS  Google Scholar 

  8. Siatecka, M. et al. Proc. Natl. Acad. Sci. USA, published online, doi:10.1073/pnas.1004996107 (9 August 2010).

  9. Menzel, S. & Thein, S.L. Curr. Opin. Hematol. 16, 179–186 (2009).

    Article  CAS  Google Scholar 

  10. Sankaran, V.G. et al. Nature 460, 1093–1097 (2009).

    Article  CAS  Google Scholar 

  11. Zhou, D., Pawlik, K.M., Ren, J., Sun, C.W. & Townes, T.M. J. Biol. Chem. 281, 16052–16057 (2006).

    Article  CAS  Google Scholar 

  12. Donze, D., Townes, T.M. & Bieker, J.J. J. Biol. Chem. 270, 1955–1959 (1995).

    Article  CAS  Google Scholar 

Download references

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  1. Department of Developmental and Regenerative Biology, James J. Bieker is at the Mount Sinai School of Medicine, New York, New York, USA.,

    James J Bieker

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  1. James J Bieker
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Correspondence to James J Bieker.

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Bieker, J. Putting a finger on the switch. Nat Genet 42, 733–734 (2010). https://doi.org/10.1038/ng0910-733

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