The discovery that a cocktail of transcription factors can reprogram somatic cells into induced pluripotent stem (iPS) cells keeps revealing new secrets of cell fate specification. A new study with hematopoietic cells shows that progenitor cells are far more susceptible than differentiated cells to reprogramming.
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Graf, T. An uphill battle toward pluripotency. Nat Genet 41, 960–961 (2009). https://doi.org/10.1038/ng0909-960
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DOI: https://doi.org/10.1038/ng0909-960
