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Hedgehog in Wnterland

Hedgehog signaling has a key role in hair follicle development, as well as in induction of the most common cancer in individuals of European descent, basal cell carcinoma (BCC). A new study shows that BCCs strongly resemble embryonic hair follicles and that BCC induction requires active Wnt/β-catenin signaling.

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Figure 1: Comparison of signaling events in basal cell carcinoma cells and hair follicle buds.

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Roop, D., Toftgård, R. Hedgehog in Wnterland. Nat Genet 40, 1040–1041 (2008). https://doi.org/10.1038/ng0908-1040

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