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Casting a wider net for diabetes susceptibility genes

Recent successes in identifying loci involved in predisposition to type 2 diabetes have been driven by genome-wide association studies in populations of European descent. A new discovery, using samples of East Asian origin, of diabetes susceptibility variants mapping to the KCNQ1 gene highlights the importance of extending these studies to a wider range of populations.

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Figure 1: Power to detect variants of similar effect size but differing risk-allele frequency.

References

  1. Frayling, T.M. Nat. Rev. Genet. 8, 657–662 (2007).

    Article  CAS  PubMed  Google Scholar 

  2. Zeggini, E. et al. Nat. Genet. 40, 638–645 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Unoki, H. et al. Nat. Genet. 40, 1098–1102 (2008).

    Article  CAS  PubMed  Google Scholar 

  4. Yasuda, K. et al. Nat. Genet. 40, 1092–1097 (2008).

    Article  CAS  PubMed  Google Scholar 

  5. McCarthy, M.I. et al. Nat. Rev. Genet. 9, 356–369 (2008).

    Article  CAS  PubMed  Google Scholar 

  6. Grant, S.F. et al. Nat. Genet. 38, 320–323 (2006).

    Article  CAS  PubMed  Google Scholar 

  7. Neyroud, N. et al. Nat. Genet. 15, 186–189 (1997).

    Article  CAS  PubMed  Google Scholar 

  8. Ullrich, S. et al. Pflugers Arch. 451, 428–436 (2005).

    Article  CAS  PubMed  Google Scholar 

  9. Pascoe, L. et al. Diabetes 56, 3101–3104 (2007).

    Article  CAS  PubMed  Google Scholar 

  10. Lee, M.P. et al. Nat. Genet. 15, 181–185 (1997).

    Article  PubMed  Google Scholar 

  11. Smilinich, N.J. et al. Proc. Natl. Acad. Sci. USA 96, 8064–8069 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ng, M.C. et al. Diabetes 57, 2226–2233 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Omori, S. et al. Diabetes 57, 791–795 (2008).

    Article  CAS  PubMed  Google Scholar 

  14. Sanghera, D.K. et al. BMC Med. Genet. 9, 59 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Neel, J.V. Am. J. Hum. Genet. 14, 353–362 (1962).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

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McCarthy, M. Casting a wider net for diabetes susceptibility genes. Nat Genet 40, 1039–1040 (2008). https://doi.org/10.1038/ng0908-1039

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  • DOI: https://doi.org/10.1038/ng0908-1039

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