Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse

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Figure 1: IREB2-deficient mice show largely normal locomotion and similar histological and ultrastructural brain morphologies as wild-type mice.


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We thank M. Hrabé de Angelis and the German Mouse Clinic for their work and the staff of the EMBL animal house and C. Schneider for technical assistance. This work was supported in part by the Bundesministerium für Bildung und Forschung/Nationales Genomforschungsnetz and Eumorphia (grant no. EU QLG2-CT-2002-00930), and by funds from the Gottfried-Wilhelm-Leibniz-Prize to M.W.H.

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Supplementary information

Supplementary Fig. 1

IREB2-deficient mice display altered ferritin and TFR1 expression in the brain. (PDF 119 kb)

Supplementary Fig. 2

Assessment of balance and motor coordination in wild-type versus IREB2-deficient mice using the accelerating rotarod. (PDF 67 kb)

Supplementary Table. 1

Total non-heme iron content in the brain of IREB2-deficient mice versus wild-type mice. (PDF 42 kb)

Supplementary Table. 2

Phenotyping of wild-type versus IREB2-deficient mice using the modified hole board test. (PDF 126 kb)

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