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Elucidating mouse transmission ratio distortion

A proportion of wild mice carry a variant region of chromosome 17 that results in severe transmission ratio distortion in males. The genetic basis of this distortion has long been enigmatic, but a recent study begins to disentangle it.

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Figure 1: Structure of the t complex and its proposed action on sperm function.

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Lyon, M. Elucidating mouse transmission ratio distortion. Nat Genet 37, 924–925 (2005). https://doi.org/10.1038/ng0905-924

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