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Unraveling the Fanconi anemia–DNA repair connection

How the Fanconi anemia chromosome stability pathway functions to cope with interstrand crosslinks and other DNA lesions has been elusive. The identification of two new Fanconi anemia–associated proteins with helicase motifs, FANCM and BRIP1 (also called FANCJ or BACH1), implicates the FANC nuclear core complex in recognizing or processing damaged DNA and the BRIP1 helicase as acting independently of this complex.

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Figure 1: Speculative model of how Fanconi anemia–associated proteins repair interstrand crosslinks during DNA replication.


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Thompson, L. Unraveling the Fanconi anemia–DNA repair connection. Nat Genet 37, 921–922 (2005).

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