The technical problem of detecting the retrotransposition—amplification and genomic dispersion of sequences through an RNA intermediate—of Pol III–directed transcripts has been solved. This provides a long-sought experimental system to learn how Alu repeats amplified to a high copy number in human DNA.
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Schmid, C. Alu: a parasite's parasite?. Nat Genet 35, 15–16 (2003). https://doi.org/10.1038/ng0903-15
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DOI: https://doi.org/10.1038/ng0903-15
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